Program

18.00h possibility to visit the Anatomic Museum. See social program. This museum is next to the lecture hall.

18.30h Registration

19.00h Opening lecture by Prof.dr. Frans Claas

His-stoRI: Reproductive Immunology and Immunogenetics at a glance

Prof.dr. Frans Claas is emeritus professor “Immunogenetics of transplantation” at the Leiden University Medical Center in Leiden, the Netherlands. The main topics of his research are the differential immunogenicity of HLA mismatches in clinical transplantation and the immunology of pregnancy as a model for transplantation tolerance. The studies of his research group have generated more than 700 papers in peer-reviewed journals. He was the initiator of a very successful program within Eurotransplant to enhance transplantation of highly sensitised renal transplant patients on basis of acceptable HLA mismatches.

19.45h Drinks + Live Music!! Hepatho-bar LUMC

Location: Hepatho is situated in the main building of the LUMC, (ground floor, K-area). From the lecture hall it is 2 minutes walk.

Please note that some bites will be served, but not enough to fill your tummy.

08:00 Registration

NEW METHODS AND TOOLS IN REPRODUCTIVE IMMUNOLOGY

08:30 Key note: Utilizing primary HLA-G+ EVT and EVT-like cell lines to study maternal-fetal interactions

Tamara Tilburgs

08:55 Tissue-Specific Immune Variation and Reconstitution in the Human Uterus

Niklas Björkström

09:20 Lactobacillus crispatus Surface Layer Proteins, multifaceted players of women’s health

Alexiane Decout

Selected orals 

09:45 The effect of co-inhibitory ligand expression by extravillous trophoblasts on conventional CD4+ T cell phenotype

Liseanne van ‘t Hof

10:00 Enhancing revascularization in ovarian tissue transplantation through ovarian endothelial cell supplementation: a novel therapeutical approach

Mariagiulia Spazzapan

10:15 Impact of TCR and BCR signaling on vaccination response in pregnant women

Kristin Thiele

10:30 Coffee/tea

AUTO-IMMUNE OR AUTO-INFLAMMATORY DISEASES, AND REPRODUCTION

11:00 Key note: How the Ingenuity of Pregnancy Informs and is Informed by Autoimmunity and Microchimerism

Lee Nelson

11:25 Role of T-cell cytokines produced during pregnancy on autoimmune disorders and inflammatory diseases activity

Marie-Pierre Piccinni

11:50 Proof-of-concept that microchimeric cells arising from pregnancy are able to produce rheumatoid arthritis-specific autoantibodies 

Nathalie Lambert 

Selected orals

12:15 The FaMaLE study: investigating failing maternal-fetal tolerance in pregnant women with SLE

Wendy Dankers

12:30 Understanding the role of immune mediated inflammatory disease-related cytokines IL-17 and IL-23 in pregnancy

Liana Barenbrug

12:45 Lunch

PREECLAMPSIA: IMMUNOLOGIC ETIOLOGY AND BIOMARKERS OF OUTCOME

13:45 Preeclampsia 

Mark Spaanderman

14:10 Preeclampsia, fetal-maternal crosstalk and cardiovascular risk

Annetine Staff

14:35 Galectins at the Heart of the Maternal Niche: Key Players in Feto-Maternal Harmony and the Path to Preeclampsia

Sandra Blois

15:00 High-dimensional profiling of maternal immune dynamics and the maternal-fetal immune landscape in preeclampsia 

Dorien Feyaerts

Selected oral

15:25 Prediction of hypertensive complications in oocyte donation pregnancy using fetal-maternal HLA-mismatches and PIRCHE-II scores: a multicenter cohort study in The Netherlands

Géraldine Lafeber

15:40 Coffee/tea

16:00 Poster session

MATERNAL-FETAL EXCHANGE, INTERACTION, AND CLINICAL IMPLICATIONS

16:55 Autologous immune cell transfer through the human placenta in an ex vivo perfusion system

Udo Markert

17:20 Is personalized management possible for FNAIT?

Joanne Verweij

17:45 Regulation of human placentation by uterine Natural Killer cells

Ashley Moffett

08:00 Registration

MALE REPRODUCTIVE IMMUNOLOGY, ENDOMETRIAL IMMUNITY, AND IMPLANTATION FAILURE

08:30 Immunological alterations in subfertile men

Jean-Pierre Allam

08:55 MAIA, the human-specific oocyte ligand, facilitates gamete membrane fusion

Katerina Komrskova

09:20 Immune polymorphic marker expression in sperm quality evaluation

Irene Athanassakis

Selected orals 

09:45 N-Acetylcysteine prevents Acetaminophen-induced subfertility in mice

Maria Victoria Bazzano

10:00 The immune-silenced dialogue in endometrial cancer TME escape: could the volume be tuned up by the fetal-maternal immune tolerance cross-talk?

Valentina Bruno

10:15 Galectin-1: A Key Regulator of Ovarian Follicle Balance and Angiogenesis Under Controlled Ovarian Hyperstimulation

Xue Wang

10:30 Coffee/tea

BEST ABSTRACT SESSION – ORAL PRESENTATIONS

11:00 Dysregulated immune checkpoint inhibitor expression is evident in women with chronic histiocytic intervillositis before they conceive 

Emily Cornish

11:15 Decidual natural killer cells promote extravillous trophoblast developmental pathways: evidence from trophoblast organoid co-cultures

Morgan L. Zych

11:30 Differential Effect of Prenatal Challenges on Fetal Microglia in Mice

Ragnar Rabe

11:45 Maternal-fetal HLA compatibility and pregnancy outcome in a genetically isolated population

Liseanne van ‘t Hof

BEST POSTER SESSION – ORAL PITCH PRESENTATIONS

12:00 Oral – best poster

12:05 Oral – best poster

12:10 Oral – best poster

12:15 Oral – best poster

12:30 Lunch

12:45 General assembly ESRI 

PRECONCEPTIONAL IMMUNOLOGICAL CHALLENGES

14:00 Key note: Menstrual Effluent Analysis: Emerging Insights into Endometriosis Diagnosis and Treatment

Christine Metz

14:25 Periconception microbiome & immunology

Sam Schoenmakers

14:50 Endometrial immune profiling and targeted therapy increase live birth rate after embryo transfer

Nathalie Ledée

Selected orals

15:15 Exploring the Impact of an Anti-inflammatory Diet on Pain and Inflammatory Markers in Women with Endometriosis: a Feasibility Study

Aysel Gurbanova

15:30 Maternal galectin signature in pregnancy is related to insulin resistance

Mariana Garcia

15:45 T-helper cells populations in the endometrium and peripheral blood during the window of implantation

Rumiana Ganeva

16:00 Coffee/tea

PLACENTA MORPHOLOGY AND INFLAMMATION

16:30 Prevention of recurrent placental rejection with an anti transplant rejection regimen

David Williams

16:55 Placental pathology

Lotte van der Meeren

17:20 3D organoid cultures to model cellular interactions in early human placentation

Sandra Haider

Selected orals 

17:45 Neutrophil Heterogeneity and Function in Early Placental Development: Regulators of trophoblast invasion?

Julia Kargl

18:00 Tacrolimus and hydroxychloroquine have no acute effects on placental explant morphology and immune cell composition

Chloe Brady

18:15 Prevalence and association of placental lesions with obstetrical features and outcome: data from French prospective study

Noémie Abisror

19:30 Conference Dinner + Awards

08:30 Registration

PRETERM BIRTH AND IMMUNOLOGY

9:00 Adverse neonatal outcomes following antenatal infection and mechanical ventilation in preterm born lambs; charting paths for cell based interventions

Tim Wolfs

9:25 Single-Cell Proteomic and Transcriptomic Immune Signatures Preceding Spontaneous

Preterm Birth

Ina Stelzer

Selected orals

9:50 Chemokine Receptor Patterns and Trophoblast-Regulated Cytokine Production in Peripheral Gamma/delta T Cells During Early Human Pregnancy: Insights into Potential Migratory Pathways

Banan Alrawashdeh

10:05 Engagement of CD96 (TACTILE) on human uterine NK cells contributes to cell activation

Corinna Mayer

10:20 Coffee/tea

RECURRENT PREGNANCY LOSS: IMMUNOLOGICAL ETIOLOGY AND IMMUNOTHERAPY 

10:50 Prevention of Recurrent Pregnancy Loss by Prednisolone? Yentl Béquet

Siobhan Quenby 

11:15 Immunotherapy in Recurrent Pregnancy Loss, (why) do we need RCTs?

Lisa Lashley

11:40 The potential of lifestyle changes in recurrent pregnancy loss

Tess Meuleman

Selected orals 

12:05 Impact of moderate aerobic exercise intervention on Natural Killer cells in women with unexplained Recurrent Pregnancy Loss

Amber Lombardi

12:20 Intravenous immunoglobulin and prednisolone to women with unexplained recurrent pregnancy loss undergoing assisted reproductive technology treatment: a randomized, double-blinded, placebo-controlled trial

Ole Christiansen

12:35 IL-34 regulated by HNF4A/circ_100737/GRP78 axis impairs placentation and 

maternal-fetal tolerance in recurrent pregnancy loss

Songcun Wang

12:50 Lunch

TRANSFER OF IMMUNITY AND PATHOGENS TO THE FETUS

13:45 Prenatal modulation of infant immunity against infection

Petra Arck

14:10 Extracellular vesicle messaging between the immune system and the placenta

Beth Holder

14:35 Semi live C section Marie-Louise van der Hoorn

15:00 Thank you and good-bye